To enable a new generation of anti-viral vaccines, we designed self-assembling protein nanoparticles with geometries tailored to present the ectodomains of influenza, HIV, and RSV viral glycoprotein trimers. Multivalent presentation of viral glycoproteins can substantially increase the elicitation of antigen-specific antibodies. Howard Hughes Medical Institute, University of Washington, United States.Center for Advanced Mathematics in Energy Research Applications, Computational Research Division, Lawrence Berkeley Laboratory, United States.Amsterdam UMC, Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, University of Amsterdam, Netherlands.Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley Laboratory, United States.Electron Microscopy Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, United States.Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, United States.Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States.International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, United States.Department of Integrative Structural and Computational Biology, The Scripps Research Institute, United States.Institute for Protein Design, University of Washington, United States.Department of Biochemistry, University of Washington, United States.
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